Department of Neuroendovascular therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.
Brain Res. 2010 Mar 31;1322:144-52. doi: 10.1016/j.brainres.2010.01.044. Epub 2010 Jan 28.
The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneurysms in rats. Eighty-three rats underwent aneurysm induction. Seven groups of 10-14 rats were treated with low or high dose olmesartan, low or high dose pravastatin, low doses of olmesartan and pravastatin, hydralazine, or no drug (control) for 12weeks, when rats were sacrificed for vascular corrosion casting and scanning electron microscopy. Aneurysmal changes at the anterior cerebral-olfactory artery bifurcation were divided into stages 0 (no abnormality) to III (saccular aneurysm). Systolic arterial blood pressure was elevated over 170mmHg in the control, low dose pravastatin, and high dose pravastatin groups, but not in the other groups. The control group demonstrated aneurysmal changes in 100% and stage III in 50% of rats. Aneurysmal changes were observed in most rats in the other groups, but the incidence of stage III was 10% or less. The staging pattern showed significant differences between the groups (P=0.028). Pravastatin reduced both stages III and II+III and olmesartan ameliorated stage III, implying that these may prevent aneurysmal formation through acting on different steps. (209 words).
颅内动脉瘤的主要形成过程被认为涉及到血管内皮功能障碍，这是由于血流动力学应激所致。血管紧张素 II 型 1 型受体阻滞剂和他汀类药物可改善血管内皮功能。本研究旨在探讨奥美沙坦和普伐他汀对大鼠实验性动脉瘤形成的影响。83 只大鼠接受了动脉瘤诱导。7 组 10-14 只大鼠分别给予低或高剂量奥美沙坦、低或高剂量普伐他汀、低剂量奥美沙坦和普伐他汀、肼屈嗪或不给予药物（对照组）治疗 12 周，然后处死大鼠进行血管腐蚀铸型和扫描电镜检查。在前大脑-嗅动脉分叉处的动脉瘤变化分为 0 期（无异常）至 III 期（囊状动脉瘤）。对照组、低剂量普伐他汀组和高剂量普伐他汀组大鼠的收缩压均升高至 170mmHg 以上，但其他组大鼠的收缩压未升高。对照组大鼠中有 100%出现动脉瘤变化，50%大鼠达到 III 期。其他组大鼠中大多数都出现了动脉瘤变化，但 III 期的发生率为 10%或更低。分期模式表明各组之间存在显著差异（P=0.028）。普伐他汀降低了 III 期和 II+III 期，奥美沙坦改善了 III 期，这表明它们可能通过作用于不同的步骤来预防动脉瘤形成。（209 个单词）
