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[社区获得性肺炎:一项为期7年的描述性研究。2007年美国感染病学会/美国胸科学会标准在评估重症监护病房收治中的应用]

[Community-acquired pneumonia: a 7-years descriptive study. Usefulness of the IDSA/ATS 2007 in the assessment of ICU admission].

作者信息

Sabatier C, Peredo R, Villagrá A, Bacelar N, Mariscal D, Ferrer R, Gallego M, Vallés J

机构信息

Centro de Críticos, Hospital de Sabadell, Instituto Universitario Parc Taulí, UAB, CIBER-Enfermedades Respiratorias, España.

出版信息

Med Intensiva. 2010 May;34(4):237-45. doi: 10.1016/j.medin.2009.11.008. Epub 2010 Jan 29.

Abstract

OBJECTIVE

To describe the clinical characteristics and outcomes of patients with community-acquired pneumonia (CAP) admitted to the Intensive Care Unit (ICU). To evaluate new ATS/IDSA criteria to identify patients with CAP who required admission to ICU.

DESIGN

Retrospective analysis of prospective collected data in a 7-year period (2000-2007).

SETTING

Medical-surgical ICU with 16 beds.

PATIENTS

All patients with severe CAP admitted to the ICU (n=147). PRIMARY ENDPOINTS: Clinical and microbiological characteristics. Prognostic factors. Comparison of patients admitted in the ICU and ATS/IDSA criteria (group 1: > or = 1 major criterion, group 2: > or = 3 minor criteria and group 3: no criterion).

INTERVENTION

None.

RESULTS

Admission to the ICU is required for patients with acute respiratory failure (60.5%) and with septic shock (28.5%). A total of 71.4%, had an identifiable microbial etiology, S. pneumoniae being the most frequently isolated. Mean time to antibiotic therapy was 4.3+/-4.2h, this being adequate in 97.1%. ICU global mortality rate was 32%. Prognostic factors associated with higher mortality were acute renal failure (OR:4.7), mechanical ventilation (OR:3.4), non-identifiable etiology (OR:4.2) and non-S. pneumonia etiology (OR:3.5). Sixty-eight percent of the patients were included in the first group of the ATS/IDSA criteria and 21% in the second group.

CONCLUSIONS

CAP mortality is still high despite early antibiotic therapy, especially in those patients with a non-S. pneumonia etiology or who require mechanical ventilation. Almost 90% of the ICU admissions were identified by the new criteria from ATS/IDSA.

摘要

目的

描述入住重症监护病房(ICU)的社区获得性肺炎(CAP)患者的临床特征及预后。评估美国胸科学会(ATS)/美国感染病学会(IDSA)用于识别需要入住ICU的CAP患者的新标准。

设计

对7年期间(2000 - 2007年)前瞻性收集的数据进行回顾性分析。

设置

拥有16张床位的内科 - 外科ICU。

患者

所有入住ICU的重症CAP患者(n = 147)。

主要终点

临床和微生物学特征。预后因素。比较入住ICU的患者与ATS/IDSA标准(第1组:≥1项主要标准;第2组:≥3项次要标准;第3组:无标准)。

干预措施

无。

结果

急性呼吸衰竭患者(60.5%)和感染性休克患者(28.5%)需要入住ICU。共有71.4%的患者有可识别的微生物病因,肺炎链球菌是最常分离出的病原体。抗生素治疗的平均时间为4.3±4.2小时,其中97.1%的治疗是充分的。ICU总体死亡率为32%。与较高死亡率相关的预后因素为急性肾衰竭(比值比:4.7)、机械通气(比值比:3.4)、不可识别的病因(比值比:4.2)和非肺炎链球菌病因(比值比:3.5)。68%的患者符合ATS/IDSA标准的第一组,21%符合第二组。

结论

尽管早期进行了抗生素治疗,但CAP的死亡率仍然很高,尤其是那些非肺炎链球菌病因或需要机械通气的患者。几乎90%入住ICU的患者可通过ATS/IDSA的新标准识别出来。

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