CBFA2T3-ZNF651 与 CBFA2T3-ZNF652 一样，充当转录共抑制复合物的功能。

CBFA2T3-ZNF651, like CBFA2T3-ZNF652, functions as a transcriptional corepressor complex.

机构信息

Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and SA Pathology, Adelaide, SA, Australia.

出版信息

FEBS Lett. 2010 Mar 5;584(5):859-64. doi: 10.1016/j.febslet.2010.01.047. Epub 2010 Jan 30.

DOI:10.1016/j.febslet.2010.01.047

PMID:20116376

Abstract

A significant proportion of the human genome codes for transcription factors. Balanced activity of transcriptional activators and repressors is essential for normal development and differentiation. Previously we reported that a classical C2H2 zinc finger DNA binding protein ZNF652 functionally interacts with CBFA2T3 to repress transcription of genes containing ZNF652 consensus DNA binding sequence within the promoters of these target genes. Here we show that ZNF651 is a ZNF652 paralogue that shares a common DNA binding sequence with ZNF652 and represses target gene expression through the formation of a CBFA2T3-ZNF651 corepressor complex. It is suggested that CBFA2T3-ZNF651 and CBFA2T3-ZNF652 repressor complexes perform functionally similar roles in a tissue-specific manner.

摘要

人类基因组的很大一部分编码转录因子。转录激活因子和抑制剂的平衡活性对于正常的发育和分化是必不可少的。以前我们报道过，一种经典的 C2H2 锌指 DNA 结合蛋白 ZNF652 与 CBFA2T3 功能相互作用，以抑制这些靶基因启动子中包含 ZNF652 共有 DNA 结合序列的基因的转录。在这里，我们表明 ZNF651 是 ZNF652 的一个旁系同源物，它与 ZNF652 具有共同的 DNA 结合序列，并通过形成 CBFA2T3-ZNF651 共抑制复合物来抑制靶基因的表达。这表明 CBFA2T3-ZNF651 和 CBFA2T3-ZNF652 抑制复合物以组织特异性的方式发挥功能相似的作用。