Danda Anil Kumar, Wahab Abdul, Narayanan Vinod, Siddareddi Avinash
Saveetha Dental College, Saveetha University, Chennai, India.
J Oral Maxillofac Surg. 2010 Feb;68(2):344-6. doi: 10.1016/j.joms.2009.09.081.
The purpose of this study was to evaluate the prophylactic value of single-dose antibiotic prophylaxis on postoperative infection in patients undergoing orthognathic surgery, compared to single-day antibiotics.
One hundred fifty patients were included in the study; 57 males and 93 females were divided into 2 groups with 75 in each group. Group 1 received a single dose of antibiotic prophylaxis and group 2 received a single day of antibiotic prophylaxis. These patients were assessed for rates of infection postoperatively after orthognathic surgery.
Seven patients (9.3%) in group 1 developed infection, whereas 2 patients (2.6%) in group 2 developed infection. The difference in rates of infection in both groups was of interest but not statistically significant (P > .05).
The results from the present study show that there is a clinically significant difference, but no statistically significant difference, between single-dose antibiotic prophylaxis and single-day antibiotic prophylaxis in reducing the rates of infection in orthognathic procedures. We recommend further studies with a larger sample size to determine whether there truly is no statistical difference between both groups.
本研究的目的是评估与单日使用抗生素相比，单剂量抗生素预防对正颌手术患者术后感染的预防价值。
150例患者纳入本研究；57例男性和93例女性被分为2组，每组75例。第1组接受单剂量抗生素预防，第2组接受单日抗生素预防。对这些患者进行正颌手术后的术后感染率评估。
第1组7例患者（9.3%）发生感染，而第2组2例患者（2.6%）发生感染。两组感染率的差异值得关注，但无统计学意义（P＞0.05）。
本研究结果表明，在降低正颌手术感染率方面，单剂量抗生素预防与单日抗生素预防之间存在临床显著差异，但无统计学显著差异。我们建议进行更大样本量的进一步研究，以确定两组之间是否真的没有统计学差异。
