Fernández David Iturbe, Sánchez Ricardo Peris, Moreno Alicia Ferreira, Fernández Fabrellas Estrella
Hospital Universitario Marqués de Valdecilla, Santander, España.
Arch Bronconeumol. 2009;45 Suppl 3:3-8. doi: 10.1016/S0300-2896(09)72851-0.
Diffuse interstitial lung disease is a heterogeneous group of diseases in which the common denominator is involvement of the area between the basement membrane of the alveolar epithelium and the capillary endothelium, known as the interstitial space. Diffuse interstitial lung disease poses a tremendous challenge to the clinician due to the diagnostic approach, the complications that can appear in the natural history of these entities, and the scarcity of available therapeutic resources. This brief review discusses key features of the management of diffuse interstitial pulmonary disease, such as prognostic factors, the therapeutic options -including the role of lung transplantation- and the diagnosis and treatment of two complications with crucial impact on the clinical course of the disease: exacerbations and associated pulmonary hypertension.
弥漫性间质性肺疾病是一组异质性疾病，其共同特征是肺泡上皮基底膜和毛细血管内皮之间的区域（即间质空间）受累。由于诊断方法、这些疾病自然病程中可能出现的并发症以及可用治疗资源的稀缺性，弥漫性间质性肺疾病给临床医生带来了巨大挑战。本简要综述讨论了弥漫性间质性肺疾病管理的关键特征，如预后因素、治疗选择（包括肺移植的作用）以及对疾病临床进程有关键影响的两种并发症的诊断和治疗：病情加重和相关肺动脉高压。
