Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Comp Biochem Physiol B Biochem Mol Biol. 2010 Apr;155(4):341-53. doi: 10.1016/j.cbpb.2010.01.010. Epub 2010 Jan 29.
In unicellular eukaryotes, apoptosis-like cell death occurs during development, aging and reproduction, and can be induced by environmental stresses and exposure to toxic agents. The essence of the apoptotic machinery in unicellular organisms is similar to that in mammals, but the apoptotic signal network is less complex and of more ancient origin. The review summarizes current data about key apoptotic proteins and mechanisms of the transduction of apoptotic signals by caspase-like proteases and mitochondrial apoptogenic proteins in unicellular eukaryotes. The roles of receptor-dependent and receptor-independent caspase cascades are reviewed.
在单细胞真核生物中，凋亡样细胞死亡发生在发育、衰老和繁殖过程中，并可由环境压力和接触有毒物质诱导。单细胞生物中凋亡机制的本质与哺乳动物相似，但凋亡信号网络较为简单，起源更为古老。该综述总结了目前关于关键凋亡蛋白以及半胱氨酸蛋白酶样蛋白酶和线粒体凋亡蛋白在单细胞真核生物中转导凋亡信号的机制的相关数据。本文还回顾了受体依赖性和受体非依赖性半胱天冬酶级联反应的作用。
