心脏病中的微小RNA：潜在的新型治疗靶点？
microRNAs in heart disease: putative novel therapeutic targets?
作者信息
Condorelli Gianluigi, Latronico Michael V G, Dorn Gerald W
机构信息
MultiMedica Hospital, Via G. Fantoli 16/15, 20138 Milan, Italy.
出版信息
Eur Heart J. 2010 Mar;31(6):649-58. doi: 10.1093/eurheartj/ehp573. Epub 2010 Jan 29.
Abstract
microRNAs (miRs) are short, approximately 22-nucleotide-long non-coding RNAs involved in the control of gene expression. They guide ribonucleoprotein complexes that effect translational repression or messenger RNA degradation to targeted messenger RNAs. miRs were initially thought to be peculiar to the developmental regulation of the nematode worm, in which they were first described in 1993. Since then, hundreds of different miRs have been reported in diverse organisms, and many have been implicated in the regulation of physiological processes of adult animals. Of importance, misexpression of miRs has been uncovered as a pathogenic mechanism in several diseases. Here, we first outline the biogenesis and mechanism of action of miRs, and then discuss their relevance to heart biology, pathology, and medicine.
摘要
微小RNA（miRs）是一类短的、长度约为22个核苷酸的非编码RNA，参与基因表达的调控。它们引导核糖核蛋白复合物对靶向信使RNA进行翻译抑制或信使RNA降解。miRs最初被认为是线虫发育调控所特有的，1993年在该线虫中首次被描述。从那时起，在多种生物体中已报道了数百种不同的miRs，并且许多miRs与成年动物生理过程的调控有关。重要的是，miRs的表达失调已被发现是几种疾病的致病机制。在这里，我们首先概述miRs的生物发生和作用机制，然后讨论它们与心脏生物学、病理学和医学的相关性。
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