Translational Cardiomyology, Stem Cell Research Institute, Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, Herestraat 49 B-3000 Leuven, Belgium; Department of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy; Interuniversity Institute of Myology, Italy.
Translational Cardiomyology, Stem Cell Research Institute, Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, KU Leuven, Herestraat 49 B-3000 Leuven, Belgium; Regenerative Medicine Research Institute, Universitat Internacional de Catalunya, Barcelona, Spain.
Pharmacol Res. 2018 Jan;127:58-66. doi: 10.1016/j.phrs.2017.05.029. Epub 2017 Jun 17.
Non-coding RNAs (ncRNAs) are emerging players in muscle regulation. Based on their length and differences in molecular structure, ncRNAs are subdivided into several categories including small interfering RNAs, stable non-coding RNAs, microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs. miRs and lncRNAs are able to post-transcriptionally regulate many genes and bring into play several traits simultaneously due to a myriad of different targets. Recent studies have emphasized their importance in cardiac regeneration and repair. As their altered expression affects cardiac function, miRs and lncRNAs could be potential targets for therapeutic intervention. In this context, miR- and lncRNA-based gene therapies are an interesting field for harnessing the complexity of ncRNA-based therapeutic approaches in cardiac diseases. In this review we will focus on lncRNA- and miR-driven regulations of cardiac development and repair. Finally, we will summarize miRs and lncRNAs as promising candidates for the treatment of heart diseases.
非编码 RNA（ncRNA）是肌肉调节中的新兴参与者。根据其长度和分子结构的差异，ncRNA 被分为几类，包括小干扰 RNA、稳定非编码 RNA、microRNA（miR）、长非编码 RNA（lncRNA）和环状 RNA。miR 和 lncRNA 能够通过转录后调节许多基因，并由于无数不同的靶标同时发挥多种特性。最近的研究强调了它们在心脏再生和修复中的重要性。由于其表达的改变会影响心脏功能，miR 和 lncRNA 可能成为治疗干预的潜在靶点。在这种情况下，基于 miR 和 lncRNA 的基因治疗是利用 ncRNA 治疗方法的复杂性来治疗心脏疾病的一个有趣领域。在这篇综述中，我们将重点介绍 lncRNA 和 miR 驱动的心脏发育和修复调控。最后，我们将总结 miR 和 lncRNA 作为治疗心脏疾病的有前途的候选物。
