Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, FIN-00014 Helsinki, Finland.
J Clin Endocrinol Metab. 2010 Apr;95(4):1793-801. doi: 10.1210/jc.2009-2348. Epub 2010 Jan 29.
Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status.
The aim was to study ethnic differences in lipid profiles stratified by glucose levels.
Data from 31 study cohorts of 12 countries, consisting of 24,760 men and 27,595 women aged 25-74 yr, were compared. The odds ratio for having dyslipidemia was estimated for each ethnic group stratified by glucose categories.
Compared with central and northern Europeans, multivariable adjusted odds ratios (95% confidence intervals) for having lower high-density lipoprotein-cholesterol were 4.74 (4.19-5.37), 5.05 (3.88-6.56), 3.07 (2.15-4.40), and 2.37 (1.67-3.35) in Asian Indian men, but 0.12 (0.09-0.16), 0.07 (0.04-0.13), 0.11 (0.07-0.20), and 0.16 (0.08-0.32) in Chinese men who had normoglycemia, prediabetes, and undiagnosed and diagnosed diabetes, respectively. Similar results were obtained for women. The prevalence of low high-density lipoprotein-cholesterol remained higher in Asian Indians (62.8% of the nondiabetic and 67.4% of the diabetic) than in central and northern Europeans (20.3 and 37.3%), Japanese (25.7 and 34.1%), or Qingdao Chinese (15.7 and 17.0%), even in individuals with low-density lipoprotein-cholesterol of less than 3 mmol/liter.
There are distinct patterns of lipid profiles associated with ethnicity regardless of the glucose levels, suggesting that ethnic-specific strategies and guidelines on risk assessment and prevention of cardiovascular disease are required.
血脂异常与高血糖并存。然而，在血糖水平相当的情况下，不同种族的血脂谱差异知之甚少。
本研究旨在研究按血糖水平分层的不同种族之间的血脂谱差异。
比较了来自 12 个国家的 31 个研究队列的数据，包括 24760 名男性和 27595 名年龄在 25-74 岁的女性。按血糖类别对每个种族组进行分层，估计血脂异常的优势比。
与中欧和北欧人相比，南亚裔男性的高密度脂蛋白胆固醇水平较低，其多变量校正后的比值比（95%置信区间）分别为 4.74（4.19-5.37）、5.05（3.88-6.56）、3.07（2.15-4.40）和 2.37（1.67-3.35），而中国男性的比值比分别为 0.12（0.09-0.16）、0.07（0.04-0.13）、0.11（0.07-0.20）和 0.16（0.08-0.32），分别为血糖正常、糖尿病前期、未诊断和诊断的糖尿病。女性也得到了类似的结果。与中欧和北欧人（非糖尿病患者的 20.3%和糖尿病患者的 37.3%）、日本人（25.7%和 34.1%）或青岛中国人（15.7%和 17.0%）相比，南亚裔的低高密度脂蛋白胆固醇血症患病率仍然较高（非糖尿病患者的 62.8%和糖尿病患者的 67.4%），即使在低密度脂蛋白胆固醇水平低于 3mmol/l 的人群中也是如此。
无论血糖水平如何，血脂谱与种族之间都存在明显的模式，这表明需要制定针对不同种族的心血管疾病风险评估和预防的具体策略和指南。
