Dept. of Neuroscience, Psychiatric Institute, University of Turin, Via Cherasco Number 11, 10126, Torino, Italy.
Psychosomatics. 2010 Jan-Feb;51(1):62-7. doi: 10.1176/appi.psy.51.1.62.
The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%.
The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects.
Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D).
Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients.
Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.
帕金森病（PD）患者的精神共病患病率约为 50%。
作者研究了接受深部脑刺激（DBS）治疗、单独用药（无 DBS）治疗的 PD 患者与健康对照者之间的差异。
每组 22 名受试者接受了特质与性格问卷（TCI）和汉密尔顿焦虑和抑郁量表（Ham-A 和 Ham-D）评估。
PD-DBS 患者在两个寻求新奇特质分量表上的得分较高。PD-DBS 患者的 Ham-A 和 Ham-D 评分低于 PD-无 DBS 患者和对照组。PD-DBS 患者的僵硬和非冲动性较 PD-无 DBS 患者低。
进一步的研究应探讨这些人格变化是否是 DBS 后运动和抑郁改善的结果。
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