Pham Uyen, Solbakk Anne-Kristin, Skogseid Inger-Marie, Toft Mathias, Pripp Are Hugo, Konglund Ane Eidahl, Andersson Stein, Haraldsen Ira Ronit, Aarsland Dag, Dietrichs Espen, Malt Ulrik Fredrik
Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway ; Department of Gerontopsychiatry, Akershus University Hospital, 1478 Lørenskog, Norway ; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.
Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway ; Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, 0027 Oslo, Norway.
Parkinsons Dis. 2015;2015:490507. doi: 10.1155/2015/490507. Epub 2015 Jan 29.
Objectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson's disease (PD). However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN-DBS in PD patients. Methods. Forty patients with advanced PD were assessed with the Temperament and Character Inventory (TCI): the Urgency, Premeditation, Perseverance, Sensation Seeking impulsive behaviour scale (UPPS), and the Neuroticism and Lie subscales of the Eysenck Personality Questionnaire (EPQ-N, EPQ-L) before surgery and after three months of STN-DBS. Collateral information obtained from the UPPS was also reported. Results. Despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the TCI Persistence and Self-Transcendence scales, after three months of STN-DBS, compared to baseline (P = 0.006; P = 0.024). Relatives reported significantly increased scores on the UPPS Lack of Premeditation scale at follow-up (P = 0.027). Conclusion. STN-DBS in PD patients is associated with personality changes in the direction of increased impulsivity.
目的。丘脑底核深部脑刺激术（STN-DBS）是一种公认的可改善晚期帕金森病（PD）运动症状的疗法。然而，其对人格的影响却知之甚少。为探讨这一话题，我们对PD患者在接受STN-DBS治疗前后的人格特质进行了评估。方法。40例晚期PD患者在手术前及STN-DBS治疗3个月后，使用气质与性格量表（TCI）、冲动行为量表（UPPS）以及艾森克人格问卷的神经质和说谎分量表（EPQ-N、EPQ-L）进行评估。同时报告从UPPS获得的相关信息。结果。尽管运动功能有所改善且多巴胺能药物剂量减少，但与基线相比，PD患者在接受STN-DBS治疗3个月后，TCI的坚持性和自我超越量表得分较低（P = 0.006；P = 0.024）。亲属报告在随访时UPPS缺乏预谋量表得分显著增加（P = 0.027）。结论。PD患者的STN-DBS与冲动性增加方向的人格变化有关。
