尼日利亚 HIV 感染者的心理困扰对药物依从性的影响。
The effect of psychological distress on medication adherence in persons with HIV infection in Nigeria.
机构信息
Dept. of Psychiatry, Lagos State University College of Medicine, Ikeja 100010, Lagos, Nigeria.
出版信息
Psychosomatics. 2010 Jan-Feb;51(1):68-73. doi: 10.1176/appi.psy.51.1.68.
BACKGROUND
A high level of adherence to prescribed antiretroviral (ARV) regimens is required to achieve and maintain suppression of human immunodeficiency virus (HIV) replication and prevent drug resistance.
OBJECTIVE
This study aimed to determine the possible relationship between psychopathology and ARV medication adherence in Nigeria.
METHOD
Persons with HIV infection (N=182) completed various questionnaires on sociodemographic and clinical details, general psychopathology, self-esteem, and medication adherence.
RESULTS
Low medication adherence was reported in 26.9% of the participants; significant correlates included presence of psychopathology and perceived poor social support.
CONCLUSION
The success of any intervention policy for HIV-infected persons in sub-Saharan Africa must consider both low level of medication adherence and its associated factors.
背景
为了实现并维持对人体免疫缺陷病毒（HIV）复制的抑制并防止药物耐药性，需要高度遵循规定的抗逆转录病毒（ARV）治疗方案。
目的
本研究旨在确定尼日利亚艾滋病毒感染者的精神病理学与 ARV 药物依从性之间可能存在的关系。
方法
182 名 HIV 感染者完成了各种问卷，内容涉及社会人口学和临床详细信息、一般精神病理学、自尊和药物依从性。
结果
报告称，有 26.9%的参与者药物依从性低；显著相关因素包括存在精神病理学和感知到的社会支持差。
结论
在撒哈拉以南非洲地区，任何针对 HIV 感染者的干预政策的成功都必须考虑到药物依从性低及其相关因素。
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