从常见青少年双相情感体验到双相情感障碍的转变预测：10 年研究。
Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study.
机构信息
Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, The Netherlands.
出版信息
Br J Psychiatry. 2010 Feb;196(2):102-8. doi: 10.1192/bjp.bp.109.065763.
BACKGROUND
Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent.
AIMS
To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes.
METHOD
In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM-IV (hypo)manic episodes and incident use of mental healthcare was assessed.
RESULTS
Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30-40% of clinical outcomes could be traced to prior persistence of affective symptoms.
CONCLUSIONS
In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.
背景
尽管（轻躁狂）症状在青少年中很常见，但向成人双相情感障碍的转变并不常见。
目的
研究亚临床情感表型持续存在的程度是否会影响向双相情感障碍转变的风险。
方法
在一项对 3021 名青少年和年轻人进行的为期 10 年的前瞻性社区队列研究中，评估了 3 年内情感症状持续存在与 10 年内出现 DSM-IV（轻躁狂）发作和使用精神保健的临床结局之间的关系。
结果
向临床结局的转变与症状的持续存在呈剂量依赖性相关。大约 30-40%的临床结局可以追溯到先前存在的情感症状。
结论
在相当一部分人群中，临床双相情感障碍的发作可能被视为一种常见的发育性、通常是短暂的非临床双相情感表型的不良结局。
Zotero 插件