Moribe Kunikazu, Kinoshita Ryo, Higashi Kenjirou, Tozuka Yuichi, Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Chem Pharm Bull (Tokyo). 2010 Feb;58(2):214-8. doi: 10.1248/cpb.58.214.
Coloration of mefenamic acid (MFA) was investigated in the presence of mesoporous silica FSM-16 with 16.0 A (Oc) and 45.0 A (Doc) pore diameter. The color change of MFA/FSM-16 physical mixture from white to deep blue was observed by sealed-heating (SH) and the subsequent humidification (HU). The coloration and the color difference were caused by the changes of chroma and lightness. In the case of MFA/FSM-16 (Oc), coloration was not observed by SH treatment only. Powder X-ray diffraction data indicated that difference of the dispersed states of MFA molecules in FSM-16 mesopore affected the coloration. MFA adsorbed on the silica surface and MFA in the mesopore were differentiated by thermogravimetric analysis. Solid-state (13)C-NMR showed that the molecular mobility of MFA was increased in the dispersed state in FSM-16 mesopores compared to the crystalline state. Structural changes of silanol groups in FSM-16 by humidification were observed by solid-state (29)Si-NMR. MFA adsorption in FSM-16 mesopore by SH as well as changes of the surface state of FSM-16 by HU affected the coloration of MFA.
在存在孔径为16.0 Å（Oc）和45.0 Å（Doc）的介孔二氧化硅FSM - 16的情况下，对甲芬那酸（MFA）的变色情况进行了研究。通过密封加热（SH）和随后的加湿（HU）观察到MFA/FSM - 16物理混合物从白色变为深蓝色。颜色变化和色差是由色度和亮度的变化引起的。在MFA/FSM - 16（Oc）的情况下，仅通过SH处理未观察到变色现象。粉末X射线衍射数据表明，MFA分子在FSM - 16介孔中的分散状态差异影响了变色情况。通过热重分析区分了吸附在二氧化硅表面的MFA和介孔中的MFA。固态（13）C - NMR表明，与结晶态相比，MFA在FSM - 16介孔中的分散态分子迁移率增加。通过固态（29）Si - NMR观察到加湿导致FSM - 16中硅醇基团的结构变化。SH导致MFA在FSM - 16介孔中的吸附以及HU导致FSM - 16表面状态的变化都影响了MFA的变色情况。
