酵母 Saccharomyces cerevisiae 基因组对氯化镍反应的 DNA 微阵列分析。

DNA microarray analysis of genomic responses of yeast Saccharomyces cerevisiae to nickel chloride.

机构信息

Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto.

出版信息

J Toxicol Sci. 2010 Feb;35(1):125-9. doi: 10.2131/jts.35.125.

DOI:10.2131/jts.35.125

PMID:20118633

Abstract

In order to investigate nickel toxicity against the yeast Saccharomyces cerevisiae, genomic responses to nickel chloride were examined using yeast DNA microarrays. Microarray analysis revealed that exposure to 25 mM nickel chloride for 2 hr induced changes in gene expression in S. cerevisiae. Nickel chloride increased expression levels in 601 genes and decreased expression levels in 696 genes in S. cerevisiae.

摘要

为了研究镍对酵母 Saccharomyces cerevisiae 的毒性，使用酵母 DNA 微阵列研究了氯化镍对基因组的反应。微阵列分析表明，暴露于 25mM 氯化镍 2 小时会导致 S. cerevisiae 中基因表达发生变化。氯化镍增加了 601 个基因的表达水平，降低了 696 个基因的表达水平。