McMahon Deanna M, Winstead Shane, Weant Kyle A
Department of Pharmacy Services, University of Kentucky HealthCare, Lexington,KY 40536, USA.
Adv Emerg Nurs J. 2009 Jul-Sep;31(3):206-13. doi: 10.1097/TME.0b013e3181ad8be8.
The ingestion of toxic alcohols, specifically ethylene glycol (EG) and methanol, provides unique therapeutic challenges for emergency personnel. If untreated, these agents can result in significant morbidity and mortality. The toxicity of EG and methanol is dependent on endogenous metabolic processes rather than the actual parent compound ingested. These metabolites lead to the characteristic metabolic acidosis and cellular dysfunction typically seen with toxic alcohol ingestions. Fortunately, several options exist for the treatment of these ingestions, which, if implemented in the appropriate time period, can significantly decrease associated morbidity and mortality. The intent of this review is to discuss relevant management issues associated with EG and methanol intoxication in the emergency department.
摄入有毒醇类，特别是乙二醇（EG）和甲醇，给急救人员带来了独特的治疗挑战。如果不进行治疗，这些物质会导致严重的发病和死亡。EG和甲醇的毒性取决于内源性代谢过程，而非所摄入的实际母体化合物。这些代谢产物会导致典型的中毒性醇类摄入所见的代谢性酸中毒和细胞功能障碍。幸运的是，对于这些摄入情况有几种治疗选择，如果在适当的时间段内实施，可显著降低相关的发病率和死亡率。本综述的目的是讨论急诊科中与EG和甲醇中毒相关的管理问题。
