School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia.
Nat Cell Biol. 2010 Feb;12(2):106-8. doi: 10.1038/ncb0210-106.
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
有丝分裂后期，动物细胞的姐妹染色单体分离仅需使着丝粒黏合蛋白的 kleisin 亚基发生切割，但要实现已分离姐妹染色单体的有效向极运动，则需要相关的 Cdk1 活性丧失。后期促进复合物/周期蛋白体的激活确保了这些事件的协调。
