Zinzani P L, Lauria F, Raspadori D, Buzzi M, Benfenati D, Bocchia M, Rondelli D, Tura S
Institute of Hematology L. e A. Seràgnoli, Bologna University, Italy.
Acta Haematol. 1991;85(1):16-9. doi: 10.1159/000204845.
In a randomized clinical trial, the effects of standard doses of alpha-interferon (alpha-IFN) compared with the effects of half of these doses were evaluated in patients with hairy cell leukemia. There were 14 patients treated with standard-dose (3 MU/day i.m. for 6 months, then 3 MU three times/week for a further 6 months) and 10 patients with low-dose alpha-IFN (1.5 MU/day with the same schedule and for the same period). The overall response rate, the quality, and the duration of response were rather similar in both groups. The rapidity of response in normalizing the peripheral blood counts was similar, even increased in low-dose-treated patients, consisting mainly in clearing the number of circulating hairy cells (p less than 0.03). Finally, the toxic effects of both regimens were minimal but less evident in patients treated with low-dose alpha-IFN. Despite the small number of patients, on the basis of this report, we can confirm that 1.5 MU/day of alpha-IFN is an adequate treatment for patients with hairy cell leukemia.
在一项随机临床试验中，对毛细胞白血病患者评估了标准剂量的α-干扰素（α-IFN）与这些剂量一半的效果。14例患者接受标准剂量治疗（每天3 MU肌肉注射，共6个月，然后每周3次，每次3 MU，再持续6个月），10例患者接受低剂量α-IFN治疗（每天1.5 MU，疗程和时间相同）。两组的总缓解率、缓解质量和缓解持续时间相当相似。外周血细胞计数恢复正常的反应速度相似，在低剂量治疗的患者中甚至有所加快，主要表现为循环中的毛细胞数量清除（p<0.03）。最后，两种治疗方案的毒性作用均最小，但在低剂量α-IFN治疗的患者中不太明显。尽管患者数量较少，但根据本报告，我们可以确认每天1.5 MU的α-IFN对毛细胞白血病患者是一种足够的治疗方法。
