Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
J Surg Oncol. 2010 Apr 1;101(5):356-62. doi: 10.1002/jso.21493.
Distant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules. This study was conducted to examine the correlation of E-cadherin/beta-catenin expression with survival and recurrence in ampullary neoplasms.
Patients with diagnoses of ampullary neoplasms were enrolled in the study. Demographics, operative findings, and histopathological data were collected by retrospective chart review. Expression of E-cadherin and beta-catenin were detected by immunohistochemistry.
A total of 110 patients were enrolled in the study. Preservation of membranous staining of E-cadherin was noted in 41 (37%) patients, aberrant cytoplasmic staining in 48 (44%) patients, and complete loss in 21 (19%) patients. Loss of E-cadherin was associated with pancreatic invasion, recurrence, and poor prognosis. Membranous staining of beta-catenin was noted in 65 (59%) patients, cytoplasmic or nuclear accumulation in 16 (15%) patients, and complete loss in 29 (26%) patients. Loss of beta-catenin expression was associated with tumor markers, ulcerative type, liver metastases, and poor prognosis. Pancreatic invasion, lymph node involvement, and loss of beta-catenin expression were predictors of disease recurrence.
Loss of the E-cadherin/beta-catenin complex is related to poor prognosis in ampullary cancer. Loss of beta-catenin is predictor of recurrence in multivariate analysis.
癌细胞从原发性肿瘤上脱离并转移到远处涉及黏附分子的改变。本研究旨在探讨在壶腹肿瘤中 E-钙黏蛋白/β-连环蛋白表达与生存和复发的相关性。
本研究纳入了诊断为壶腹肿瘤的患者。通过回顾性病历审查收集人口统计学、手术发现和组织病理学数据。通过免疫组织化学检测 E-钙黏蛋白和β-连环蛋白的表达。
共纳入 110 例患者。41 例（37%）患者的 E-钙黏蛋白膜染色得到保留，48 例（44%）患者出现异常的细胞质染色，21 例（19%）患者完全丢失。E-钙黏蛋白的丢失与胰腺侵犯、复发和预后不良相关。65 例（59%）患者的β-连环蛋白出现膜染色，16 例（15%）患者出现细胞质或核内积聚，29 例（26%）患者完全丢失。β-连环蛋白表达缺失与肿瘤标志物、溃疡性类型、肝转移和预后不良相关。胰腺侵犯、淋巴结受累和β-连环蛋白表达缺失是疾病复发的预测因素。
E-钙黏蛋白/β-连环蛋白复合物的缺失与壶腹癌的不良预后相关。β-连环蛋白的缺失是多变量分析中复发的预测因素。
