Meng Wang, Xiaoliang Ren, Xiumei Gao, Vincieri Franco Francesco, Bilia Anna Rita
Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Yuquan Road, 88, 300193, Tianjin, People's Republic of China.
Nat Prod Commun. 2009 Dec;4(12):1761-76.
Studies on stability of active ingredients are fundamental and critical for the rational development of Traditional Chinese Medicine (TCM) in view of its modernization and worldwide use. The stability of both active and marker constituents of plants used in TCM is reviewed for the first time. More than 100 papers, mostly written in Chinese, have been reviewed. Studies concerning plant constituents were analyzed according to their chemical classification of active ingredients. In addition, several crude drugs of animal origin are also reported. Stability of active ingredients is summarized during extraction and/or storage of the herbal drug preparations, and under stress conditions (pH, temperature, solvents, light, and humidity) and in the presence of preservatives, antioxidants, and metals.
鉴于中药的现代化和全球应用，活性成分稳定性研究对于中药的合理开发至关重要。本文首次综述了中药所用植物中活性成分和标志性成分的稳定性。共查阅了100多篇论文，其中大部分为中文。根据活性成分的化学分类对有关植物成分的研究进行了分析。此外，还报道了几种动物源的天然药物。总结了活性成分在草药制剂提取和/或储存过程中、在应激条件下（pH值、温度、溶剂、光照和湿度）以及在防腐剂、抗氧化剂和金属存在下的稳定性。
