Aubier Michel
Pneumologie A, Hôpital Bichat--Inserm U700, Faculté de médecine Bichat, 46, rue Henri Huchard 75018 Paris.
Bull Acad Natl Med. 2009 Jun;193(6):1303-13; discussion 1313-5.
There is good evidence that urban air pollutants, and particularly diesel exhaust particles (DP), contribute to the increasing prevalence of asthma and allergic rhinitis. Diesel exhaust particles act as adjuvants in the immune response and may aggravate allergic inflammation. This was first suggested by epidemiological studies and has now been largely confirmed by numerous experimental studies in animals and humans. We review the different underlying mechanisms, including effects on cytokine and chemokine production and immune cell activation. We also discuss the metabolic and cellular activation pathways followed by polycyclic aromatic hydrocarbons and allergens, and their interaction with diesel particles, which act in synergy in this immune response, resulting in IgE production and triggering allergic inflammation.
有充分证据表明，城市空气污染物，尤其是柴油尾气颗粒（DP），导致哮喘和过敏性鼻炎的患病率不断上升。柴油尾气颗粒在免疫反应中起佐剂作用，可能会加重过敏性炎症。这一观点最早由流行病学研究提出，现在已在大量动物和人体实验研究中得到广泛证实。我们综述了不同的潜在机制，包括对细胞因子和趋化因子产生以及免疫细胞激活的影响。我们还讨论了多环芳烃和过敏原所遵循的代谢和细胞激活途径，以及它们与柴油颗粒的相互作用，这些在免疫反应中协同作用，导致IgE产生并引发过敏性炎症。
