Kircik Leon
Physicians Skin Care, Louisville, KY 40217, USA.
J Drugs Dermatol. 2010 Jan;9(1):41-8.
Scalp lesions are common among patients with psoriasis, seborrheic dermatitis and a number of other inflammatory and fungal conditions. Topical corticosteroids are a mainstay of treatment for many scalp dermatoses and they significantly reduce erythema, scaling and pruritus. Conventional corticosteroid formulations such as cream and ointments are often difficult or time consuming for patients to apply and may produce undesirable cosmetic effects. Medicated shampoos provide a more convenient alternative for patients who require topical administration of corticosteroids for scalp conditions. Tar shampoos have long been used to treat psoriasis and are effective for the long-term maintenance of remission in patients who respond to therapy. Antifungal shampoos are effective for the treatment of seborrheic dermatitis and other mycotic conditions. A shampoo formulation containing fluocinolone acetonide, 0.01% is also approved for the treatment of seborrheic dermatitis. One superpotent corticosteroid shampoo (clobetasol propionate 0.05%; Clobex Shampoo) is approved in the United States (U.S.) for once-daily treatment of psoriasis of the scalp. The results of a 2007 pilot study also demonstrated that clobetasol propionate shampoo improved the signs and symptoms of seborrheic dermatitis. These findings suggest that high-potency corticosteroid shampoos may provide an important option for topical corticosteroid therapy in dermatologic conditions affecting the scalp.
头皮病变在银屑病、脂溢性皮炎以及许多其他炎症性和真菌性疾病患者中很常见。局部用皮质类固醇是许多头皮皮肤病治疗的主要手段,它们能显著减轻红斑、脱屑和瘙痒。传统的皮质类固醇制剂,如乳膏和软膏,患者使用起来往往困难或耗时,并且可能产生不良的美容效果。药用洗发水为那些因头皮疾病需要局部使用皮质类固醇的患者提供了一种更方便的选择。煤焦油洗发水长期以来一直用于治疗银屑病,对有治疗反应的患者的缓解期长期维持有效。抗真菌洗发水对脂溢性皮炎和其他真菌性疾病的治疗有效。一种含有0.01%醋酸氟轻松的洗发水配方也被批准用于治疗脂溢性皮炎。一种超强效皮质类固醇洗发水(0.05%丙酸氯倍他索;Clobex洗发水)在美国被批准用于头皮银屑病的每日一次治疗。一项2007年的初步研究结果还表明,丙酸氯倍他索洗发水改善了脂溢性皮炎的体征和症状。这些发现表明,高效皮质类固醇洗发水可能为影响头皮的皮肤病局部皮质类固醇治疗提供一个重要选择。