Puzanowska-Tarasiewicz Helena, Kuźmicka Ludmiła, Tarasiewicz Mirosław
Wyzsza Szkoła Kosmetologii i Ochrony Zdrowia w Białymstoku, Zakład Nauk Chemicznych.
Pol Merkur Lekarski. 2009 Dec;27(162):496-8.
Reactive nitrogen species (RNS) and oxygen (ROS) species play a very positive and important role in the process of cells communication. The maintenance of certain level of radicals in cells is necessary for the information flow between cells and inside cells. The liquidation of free radicals presence or an increase in their level may to some extent disturb the cellular communication. Even slight fluctuations in the basic level of ROS significantly affect the change in the cell's metabolism, expression of genes and posttranslational modification of proteins. When the level of free oxygen radicals exceeds the antioxidative possibilities of the cell, an oxidative stress occurs, which causes many diseases and accelerated aging of the organism. Aging is natural, complex process, but apart from the programmed aging the reactive oxygen molecules, which are external agressors, accelerate this process.
活性氮物质（RNS）和氧（ROS）在细胞通讯过程中发挥着非常积极且重要的作用。维持细胞内一定水平的自由基对于细胞间以及细胞内的信息流是必要的。自由基的清除或其水平的升高在一定程度上可能会干扰细胞通讯。即使ROS基础水平的轻微波动也会显著影响细胞代谢的变化、基因表达以及蛋白质的翻译后修饰。当游离氧自由基的水平超过细胞的抗氧化能力时，就会发生氧化应激，这会导致许多疾病并加速机体衰老。衰老是一个自然、复杂的过程，但除了程序性衰老外，作为外部攻击者的活性氧分子会加速这一过程。
