Osławska-Dzierzega Anna, Dabrowska Magdalena, Hrycek Eugeniusz, Jadczyk Tomasz, Arasiewicz Hubert
Slaski Uniwersytet Medyczny w Katowicach, Katedra i Klinika Chorób Wewnetrznych, Autoimmunologicznych i Metabolicznych.
Pol Merkur Lekarski. 2009 Dec;27(162):503-7.
Haematological abnormalities are common in systemic lupus erythematosus (SLE) and may be manifested by anaemia of different pathogenesis. The objective of this article was to describe some data concerning autoimmune haemolytic anaemia, aplastic and megaloblastic ones accompanying SLE and also to present erythropoietin (EPO) function in the above mentioned diseases. In SLE many factors are produced which disturb the organism haematological balance both on the peripheral level and in the bone marrow. It is assumed that the autoantibodies produced in SLE are the main cause of anaemia. However it should be considered that quantitative changes in the number of erythrocytes observed in this disease are also caused by chronic inflammatory condition, which as the element of autoimmune disease impairs the endocrine function of the kidneys in EPO production. It influences bone marrow, iron metabolism and then haemopoiesis. Apart from humoral factors the role of mechanisms connected with immune cellular response is also considered.
血液学异常在系统性红斑狼疮（SLE）中很常见，可能表现为不同发病机制的贫血。本文的目的是描述一些关于自身免疫性溶血性贫血、再生障碍性贫血和巨幼细胞贫血伴发SLE的数据，并介绍促红细胞生成素（EPO）在上述疾病中的作用。在SLE中，会产生许多干扰外周水平和骨髓中机体血液学平衡的因素。据推测，SLE中产生的自身抗体是贫血的主要原因。然而，应该考虑到，在这种疾病中观察到的红细胞数量的定量变化也是由慢性炎症状态引起的，作为自身免疫性疾病的一个因素，它损害了肾脏在EPO产生中的内分泌功能。它影响骨髓、铁代谢，进而影响造血。除了体液因素外，与免疫细胞反应相关的机制的作用也被考虑在内。
