Lam S K, Quah T C
Department of Paediatrics, National University of Singapore.
J Singapore Paediatr Soc. 1990;32(3-4):132-6.
Anemia is a common finding in children with systemic lupus erythematosus (SLE). Anemia in SLE may result from several mechanisms and more than one may be operative at any time. Anemia of chronic disease is the most common, but a low hemoglobin can be caused by auto-antibodies to red cells as part of the auto-immunity, or it may be the result of impaired erythropoietin production by kidneys involved in the SLE, gastrointestinal blood loss from anti-inflammatory therapy, increased red cell destruction from hypersplenism or a drug-induced immune phenomenon. We briefly review the important processes that can lead to a low hemoglobin in children with SLE, their clinical features and their treatment.
贫血是系统性红斑狼疮（SLE）患儿的常见表现。SLE 中的贫血可能由多种机制引起，且在任何时候可能不止一种机制起作用。慢性病贫血最为常见，但血红蛋白降低可能是自身免疫导致的针对红细胞的自身抗体所致，也可能是 SLE 累及肾脏导致促红细胞生成素生成受损、抗炎治疗引起的胃肠道失血、脾功能亢进导致红细胞破坏增加或药物诱导的免疫现象的结果。我们简要回顾一下可导致 SLE 患儿血红蛋白降低的重要过程、其临床特征及治疗方法。
