Młynarczyk Andrzej, Winek Katarzyna, Wolska Magdalena, Caban Anna, Jabłońska Monika, Romul Monika, Wanyura Anna, Sawicka-Grzelak Anna, Młynarczyk Grazyna
Warszawskiego Uniwersytetu Medycznego.
Med Dosw Mikrobiol. 2009;61(3):221-6.
The profiles of resistance of ESBL(-) and ESBL(+) strains of Enterobacter cloacae were analysed and compared. 466 Enterobacter cloacae strains isolated from different specimens obtained from patients of big Warsaw hospital in 2004-2005 were investigated. By using the several phenotypic methods 33.5% of strains was identified as ESBL(+). ESBL(+) strains were significantly less susceptible then ESBL(-). These two groups differed mostly in susceptibility to aminoglycosides and fluoroquinolones, e.g. 65.5% of ESBL(-) strains were susceptible to gentamicin, compared to only 25.0% ESBL(+), in case of ciprofloxacin 59.0% of ESBL(-) were susceptible whereas only 25.0% of ESBL(+) strains. The percentage of ESBL(+) grew from 26.4% in 2004 to 40.4% in 2005, whereas a tendency of growing susceptibility to aminoglycosides and fluoroquinolones was noted among all E.cloacae strains. Susceptibility to combinations of piperacillin or ticarcillin with beta-lactamase inhibitor was rather low among ESBL(+) strains.
分析并比较了阴沟肠杆菌ESBL（-）和ESBL（+）菌株的耐药谱。对2004年至2005年从华沙大型医院患者的不同标本中分离出的466株阴沟肠杆菌菌株进行了研究。通过几种表型方法，33.5%的菌株被鉴定为ESBL（+）。ESBL（+）菌株的敏感性明显低于ESBL（-）菌株。这两组在对氨基糖苷类和氟喹诺酮类药物的敏感性方面差异最大，例如，65.5%的ESBL（-）菌株对庆大霉素敏感，而ESBL（+）菌株仅为25.0%；对于环丙沙星，59.0%的ESBL（-）菌株敏感，而ESBL（+）菌株仅为25.0%。ESBL（+）菌株的比例从2004年的26.4%增长到2005年的40.4%，而在所有阴沟肠杆菌菌株中都观察到对氨基糖苷类和氟喹诺酮类药物敏感性增加的趋势。ESBL（+）菌株对哌拉西林或替卡西林与β-内酰胺酶抑制剂组合的敏感性相当低。
