Kwiatek Magdalena, Kocik Janusz, Bartoszcze Michał
Wojskowy Instytut Higieny i Epidemiologii, Warszawa.
Przegl Epidemiol. 2009;63(4):487-94.
Influenza, especially pandemic influenza, poses great threat to health and humans life of. Due to the antigenic drift and shift of the influenza virus, there is a constant requirement to accurately adjust contents of the vaccine to current subtype of the virus. As there is always a long period of time between the moment of detection of a new kind of influenza virus till a new vaccine is produced, the only protection for the people are antiviral drugs. Some examples of antiviral compounds that can be used in treatment in near future have been presented. A review of the researches on the substances that are active against influenza viruses has been carried out and their mechanism of action was described. We have taken into account the chemical compounds that seem to be active in the process of virus adsorption; hemagglutinin and neuraminidase inhibitors; M2 ion channel blockers; polymerase, endonuclease, transcriptase, proteine kinase and signaling cascade inhibitors. The potential of oligonucleotide antiviral therapeutics and the substances that are extracted from different plants were presented. The future direction of research were shown.
流感，尤其是大流行性流感，对健康和人类生命构成巨大威胁。由于流感病毒的抗原漂移和转变，始终需要根据当前病毒亚型准确调整疫苗成分。从检测到新型流感病毒到生产新疫苗之间总会有很长一段时间，对人们来说唯一的保护就是抗病毒药物。文中列举了一些在不久的将来可用于治疗的抗病毒化合物实例。对针对流感病毒有活性的物质的研究进行了综述，并描述了它们的作用机制。我们考虑了在病毒吸附过程中似乎有活性的化合物；血凝素和神经氨酸酶抑制剂；M2离子通道阻滞剂；聚合酶、核酸内切酶、转录酶、蛋白激酶和信号级联抑制剂。还介绍了寡核苷酸抗病毒疗法的潜力以及从不同植物中提取的物质。展示了未来的研究方向。
