Aquilina Kristian, Merchant Thomas E, Rodriguez-Galindo Carlos, Ellison David W, Sanford Robert A, Boop Frederick A
Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom.
J Neurosurg Pediatr. 2010 Feb;5(2):155-61. doi: 10.3171/2009.9.PEDS09257.
Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.
颅咽管瘤的恶性转化是一种罕见事件；儿童中仅报告过3例，均见于日本文献。作者描述了另外2例儿科病例。这2例病例的治疗均包括多次切除术和外照射放疗（EBRT）。恶性转化发生在EBRT后7年和8年。作者还回顾了另外6例成人病例。讨论了与放疗可能的因果关系。由于放疗目前是颅咽管瘤治疗的重要选择，这种关系需要进一步研究。
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