Department of Pathology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Arch Pathol Lab Med. 2010 Feb;134(2):207-15. doi: 10.5858/134.2.207.
It is important to determine the type and/or site of origin of metastatic tumors for optimal clinical management.
To summarize the use of currently available immunohistochemical markers in the evaluation of metastatic tumors.
Review of relevant literature on immunohistochemical evaluation of tumors and the author's personal experience.
Immunohistochemistry is an important ancillary technique for evaluation of metastatic tumors and should be used in the context of routine morphology and clinical information. While a single marker may be used to support a known or suspected site of origin, a carefully constructed panel is strongly recommended, particularly for tumors of morphologically uncertain lineage or origin.
确定转移性肿瘤的类型和/或起源部位对于优化临床管理非常重要。
总结目前可用的免疫组织化学标志物在转移性肿瘤评估中的应用。
对肿瘤免疫组织化学评估相关文献的复习和作者的个人经验。
免疫组织化学是评估转移性肿瘤的重要辅助技术，应结合常规形态学和临床信息使用。虽然单个标志物可用于支持已知或可疑的起源部位，但强烈推荐精心构建的标志物组合，特别是对于形态学不确定谱系或起源的肿瘤。
