Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 150 Bergen St, UH E155, Newark, NJ 07103, USA.
Arch Pathol Lab Med. 2010 Feb;134(2):283-8. doi: 10.5858/134.2.283.
Intraosseous benign notochordal cell tumor is a presumably benign, intravertebral lesion of notochord origin, which can be found incidentally on removal of the vertebra for unrelated lesions or during an autopsy. The notion of a larger benign notochordal cell tumor that is macroscopic, occasionally symptomatic, and seen radiologically was recently introduced, and described as giant vertebral notochordal rest, giant notochordal hamartoma of intraosseous origin, and benign chordoma . Because of the location, size, and similar histologic and immunohistochemical characteristics, larger benign notochordal cell tumors are easily misdiagnosed as the malignant notochord-type of tumor/chordoma, with critical implications. In this review, we attempt to shed light on the major differences between benign notochordal cell tumors and chordoma and other related notochord lesions, such as notochordal vestiges of the intervertebral disk and ecchordosis physaliphora.
骨内良性脊索细胞肿瘤是一种源自脊索的、推测为良性的椎体内病变，通常在因其他无关病变而切除椎体或尸检时偶然发现。最近提出了一种更大的良性脊索细胞肿瘤的概念，其为大体上、偶有症状且影像学可见，被描述为巨大的椎体脊索残余、骨内起源的巨大脊索错构瘤和良性脊索瘤。由于位置、大小以及相似的组织学和免疫组化特征，较大的良性脊索细胞肿瘤很容易被误诊为恶性脊索样肿瘤/脊索瘤，具有重要的影响。在这篇综述中，我们试图阐明良性脊索细胞肿瘤与脊索瘤和其他相关脊索病变（如椎间盘脊索残余和脊索膜外体）之间的主要区别。
