Department of Clinical Neuroscience, and Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden.
Acta Paediatr. 2010 Apr;99(4):604-11. doi: 10.1111/j.1651-2227.2009.01657.x. Epub 2010 Jan 28.
The aim of this study was to investigate heart rate variability (HRV) in a clinical sample of female adolescents with anxiety disorders (AD) and/or major depressive disorder (MDD) compared with healthy controls and to assess the effect of selective serotonin reuptake inhibitors (SSRI) on HRV.
Heart rate variability was measured in adolescent female psychiatric patients with AD and/or MDD (n = 69), mean age 16.8 years (range: 14.5-18.4), from 13 out-patient clinics and in healthy controls (n = 65), mean age 16.5 years (range: 15.9-17.7). HRV was registered in the sitting position during 4 min with no interventions.
Logarithmically transformed high frequency HRV (HF), low frequency HRV (LF) and standard deviation of inter beat intervals (SDNN) were lower in the clinical sample compared with the controls (Cohen's d for HF = 0.57, LF = 0.55, SDNN = 0.60). This was not explained by body mass index, blood pressure or physical activity. Medication with SSRI explained 15.5% of the total variance of HF, 3.0% of LF and 6.5% of SDNN.
Adolescent female psychiatric patients with AD and/or MDD show reduced HRV compared with healthy controls. Medication with SSRI explained a part of this difference.
本研究旨在调查患有焦虑障碍（AD）和/或重度抑郁症（MDD）的女性青少年临床样本中的心率变异性（HRV），并与健康对照组进行比较，同时评估选择性 5-羟色胺再摄取抑制剂（SSRI）对 HRV 的影响。
在 13 家门诊诊所中，对 69 名患有 AD 和/或 MDD 的青少年女性精神科患者（平均年龄 16.8 岁，范围：14.5-18.4 岁）和 65 名健康对照者（平均年龄 16.5 岁，范围：15.9-17.7 岁）进行 HRV 测量。在没有干预的情况下，患者取坐姿记录 4 分钟的 HRV。
与对照组相比，临床样本的对数转换高频 HRV（HF）、低频 HRV（LF）和心率间隔标准差（SDNN）均较低（HF 的 Cohen's d 为 0.57，LF 为 0.55，SDNN 为 0.60）。这与体重指数、血压或体力活动无关。SSRI 药物治疗解释了 HF 总方差的 15.5%、LF 的 3.0%和 SDNN 的 6.5%。
患有 AD 和/或 MDD 的青少年女性精神科患者的 HRV 低于健康对照组。SSRI 药物治疗解释了这种差异的一部分。
