意大利肠外感染中产 CTX-M-15 耐药的大肠埃希菌 ST131 克隆株
Ciprofloxacin-resistant, CTX-M-15-producing Escherichia coli ST131 clone in extraintestinal infections in Italy.
机构信息
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Clin Microbiol Infect. 2010 Oct;16(10):1555-8. doi: 10.1111/j.1469-0691.2010.03162.x.
Quinolone and β-lactam resistance mechanisms and clonal relationships were characterized among Escherichia coli isolates resistant to ciprofloxacin and extended-spectrum cephalosporins associated with human extra-intestinal infections in Rome. The E. coli. ST131 clone was found to be prevalent. This clone invariably carried a specific pattern of substitutions in the topoisomerase genes and all isolates but one produced CTX-M-15. One ST131 isolate produced SHV-12. The new ST131 variant described here is of particular concern because it combines fluoroquinolone resistance and chromosomally encoded CTX-M-15.
在罗马，与人类肠外感染相关的对环丙沙星和广谱头孢菌素耐药的大肠杆菌分离株中，对喹诺酮和β-内酰胺耐药机制和克隆关系进行了研究。发现大肠杆菌 ST131 克隆普遍存在。该克隆总是在拓扑异构酶基因中携带特定的取代模式，除一个分离株外，所有分离株均产生 CTX-M-15。一个 ST131 分离株产生 SHV-12。这里描述的新 ST131 变体尤其令人担忧，因为它结合了氟喹诺酮耐药性和染色体编码的 CTX-M-15。
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