Andersen Vibeke Charlotte, Vogel Ulla
Medicinsk Afdeling, Regionshospitalet Viborg, DK-8800 Viborg, Denmark.
Ugeskr Laeger. 2010 Feb 1;172(5):368-71.
Both genetic and environmental factors contribute to the aetiology of many common diseases. Recently, progress has been made in the identification of susceptibility genes by candidate gene and genome-wide association studies. Thereby, a further molecular understanding of pathophysiological pathways has been obtained and the development of new therapeutic modalities based on rational drug design has been initiated. However, a host of methods and approaches are necessary to further increase the knowledge on the aetiology of the complex diseases.
遗传因素和环境因素都对许多常见疾病的病因有影响。最近，通过候选基因和全基因组关联研究在确定易感基因方面取得了进展。由此，对病理生理途径有了进一步的分子层面的理解，并启动了基于合理药物设计的新治疗方法的研发。然而，需要大量的方法和途径来进一步增加对复杂疾病病因的认识。
