分析与鼻咽血管纤维瘤复发相关的危险因素。
Analysis of risk factors associated with recurrence of nasopharyngeal angiofibroma.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Fudan University Affiliated Eye, Ear, Nose and Throat Hospital, Shanghai, China.
出版信息
J Otolaryngol Head Neck Surg. 2010 Feb;39(1):56-61.
OBJECTIVE
Surgical outcomes and prognostic factors were analyzed to determine what factors increase the probability of juvenile nasopharyngeal angiofibroma (JNA) recurrence.
METHODS
Ninety-seven males with JNA were diagnosed and underwent surgery at Fudan University Affiliated Eye, Ear, Nose and Throat Hospital from 1997 to 2006. Clinical data were extracted from medical records and were used in the statistical analysis.
RESULTS
The total recurrence rate of JNA was 39.2% after the initial surgery. A patient whose tumour staging was higher was more likely to have a recurrence than a patient whose tumour staging was lower (p = .0031). The recurrence rates in two groups (age >or= 18 years group and < 18 years group) were 26.8% and 48.2%, respectively (p = .03). The recurrence rates with tumour size < 4 cm and >or= 4 cm were 21.7% and 54.9%, respectively (p = .0008).
CONCLUSION
The significant predictors of recurrence in our study were age at diagnosis, tumour size, and Radkowski classification.
目的
分析手术结果和预后因素，以确定哪些因素会增加青少年鼻咽血管纤维瘤（JNA）复发的概率。
方法
1997 年至 2006 年，复旦大学附属眼耳鼻喉科医院诊断并手术治疗了 97 例男性 JNA 患者。从病历中提取临床资料并进行统计学分析。
结果
初次手术后 JNA 的总复发率为 39.2%。肿瘤分期较高的患者比肿瘤分期较低的患者更有可能复发（p =.0031）。两组（年龄≥18 岁组和<18 岁组）的复发率分别为 26.8%和 48.2%（p =.03）。肿瘤大小<4cm 和≥4cm 的复发率分别为 21.7%和 54.9%（p =.0008）。
结论
本研究中，复发的显著预测因素为诊断时的年龄、肿瘤大小和 Radkowski 分类。
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