孤儿核受体找到归宿。

An orphan nuclear receptor finds a home.

机构信息

Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8028, USA.

出版信息

Mol Cell. 2010 Jan 29;37(2):155-7. doi: 10.1016/j.molcel.2010.01.008.

DOI:10.1016/j.molcel.2010.01.008

PMID:20122397

Abstract

In this issue of Molecular Cell, Lee et al. (2010) show that the retinoic acid receptor-related orphan receptor alpha (RORalpha) can suppress the Wnt/beta-catenin signaling pathway in a Wnt5a- and PKC-dependent manner that does not alter beta-catenin stabilization or the recruitment of beta-catenin to Wnt target promoters.

摘要

在本期《分子细胞》中，Lee 等人（2010）表明视黄酸受体相关孤儿受体α（RORα）可以在不改变β-连环蛋白稳定或β-连环蛋白募集到 Wnt 靶启动子的情况下，以依赖 Wnt5a 和 PKC 的方式抑制 Wnt/β-连环蛋白信号通路。