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Am J Orthod Dentofacial Orthop. 2010 Jan;137(1):123-34. doi: 10.1016/j.ajodo.2007.05.029.
This case report describes the retreatment of a patient with Marfan syndrome whose earlier orthodontic and surgical treatment had been unsuccessful. Marfan syndrome is an inherited connective tissue disorder transmitted as an autosomal dominant trait. The disorder results from molecular defects in the fibrillin gene that are responsible for the impaired structural integrity of the skeletal, ocular, and cardiovascular systems. When she sought retreatment, the patient had an open bite, mandibular anterior crowding, severe root resorption, and temporomandibular joint derangement with some resorption of the condyles. The second treatment, which included extractions and surgery, resulted in balanced and harmonious facial proportions, and a Class I occlusion with normal overjet and overbite. There was no further loss of condylar tissue, and the temporomandibular joints were asymptomatic. More root resorption on the mandibular left canine and the left second premolar was evident after the second treatment.
本病例报告描述了一位马凡综合征患者的再次治疗情况，该患者之前的正畸和手术治疗均不成功。马凡综合征是一种遗传性结缔组织疾病，呈常染色体显性遗传。该疾病是由于纤维蛋白基因的分子缺陷引起的，导致骨骼、眼部和心血管系统的结构完整性受损。当她寻求再次治疗时，患者存在开颌、下颌前牙拥挤、严重的牙根吸收以及颞下颌关节紊乱，伴有髁突的一些吸收。第二次治疗包括拔牙和手术，结果获得了平衡和谐的面部比例以及正常覆颌和覆盖的 Class I 咬合关系。髁突组织没有进一步丧失，颞下颌关节无症状。第二次治疗后，下颌左侧尖牙和左侧第二前磨牙的牙根吸收更为明显。
