Developmental Origins of Health and Disease Division, University of Southampton, School of Medicine, Southampton, Hampshire, UK.
Endocrinol Metab Clin North Am. 2010 Mar;39(1):33-43, viii. doi: 10.1016/j.ecl.2009.10.003.
It is believed that insulin and insulin-like growth factor I (IGF-I) are abused by professional athletes, either alone or in combination with growth hormone (GH) and anabolic steroids. The recent introduction of IGF-I to clinical practice is likely to increase its availability and abuse. Insulin and IGF-I work together with GH to control the supply of nutrients to tissues in the fasted and fed state. The actions of insulin and IGF-I that may enhance performance include increased protein anabolism and glucose uptake and storage. The detection of IGF-I and insulin abuse is challenging. There are established mass spectrometry methods for insulin analogs. The feasibility of using GH-dependent markers to detect IGF-I use is being assessed.
人们认为，胰岛素和胰岛素样生长因子 I（IGF-I）被专业运动员滥用，无论是单独使用还是与生长激素（GH）和合成代谢类固醇联合使用。最近 IGF-I 在临床实践中的应用可能会增加其可获得性和滥用。胰岛素和 IGF-I 与 GH 一起作用，控制在禁食和进食状态下向组织供应营养。可能增强运动表现的胰岛素和 IGF-I 的作用包括增加蛋白质合成和葡萄糖摄取和储存。检测 IGF-I 和胰岛素滥用具有挑战性。已经建立了用于胰岛素类似物的质谱分析方法。正在评估使用 GH 依赖性标志物来检测 IGF-I 使用的可行性。
