Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
J Cardiol. 2010 Jan;55(1):65-8. doi: 10.1016/j.jjcc.2009.08.006. Epub 2009 Oct 4.
Recent studies have demonstrated that not only plasma low-density lipoprotein (LDL) levels, but also the number of small dense LDL particles are involved in the development of arteriosclerosis. Anion exchange resins can reduce plasma LDL levels and affect LDL particle size via increasing triglycerides. In the present study, the effects of short-term colestimide administration on LDL particle size were investigated.
Obese patients with primary hyperlipidemia (n=21) were administered 3000 mg/day of colestimide for 1 month and fasting blood was obtained before and after the treatment. LDL particle size and number were measured by nuclear magnetic resonance (NMR) lipoprofile using magnetic resonance spectroscopy.
Levels of plasma LDL cholesterol decreased from 155.5 mg/dl to 128.1 mg/dl (p<0.001) and levels of apolipoprotein B decreased from 139.2 mg/dl to 120.6 mg/dl (p<0.001) by colestimide administration. Levels of high-density lipoprotein (HDL) cholesterol and triglyceride were unaltered. LDL particle size did not change, whereas LDL particle numbers decreased from 1920.3 nmol/l to 1568.8 nmol/l (p<0.01).
Short-term administration of colestimide to patients with hyperlipidemia reduced LDL particle numbers. LDL particle size was not changed.
最近的研究表明，不仅是血浆低密度脂蛋白（LDL）水平，而且小而密 LDL 颗粒的数量也与动脉粥样硬化的发展有关。阴离子交换树脂可以通过增加甘油三酯来降低血浆 LDL 水平并影响 LDL 颗粒大小。在本研究中，研究了短期考来替泊给药对 LDL 颗粒大小的影响。
将 21 名原发性高脂血症的肥胖患者给予考来替泊 3000mg/天，治疗前后均采集空腹血。使用磁共振波谱法通过核磁共振（NMR）脂蛋白谱测量 LDL 颗粒大小和数量。
考来替泊给药后，血浆 LDL 胆固醇水平从 155.5mg/dl 降至 128.1mg/dl（p<0.001），载脂蛋白 B 水平从 139.2mg/dl 降至 120.6mg/dl（p<0.001）。高密度脂蛋白（HDL）胆固醇和甘油三酯水平不变。LDL 颗粒大小没有变化，而 LDL 颗粒数从 1920.3nmol/L 降至 1568.8nmol/L（p<0.01）。
短期给予高脂血症患者考来替泊可降低 LDL 颗粒数。LDL 颗粒大小没有改变。
