Sackler School of Medicine, Tel-Aviv University, Israel.
Eur J Intern Med. 2010 Feb;21(1):2-5. doi: 10.1016/j.ejim.2009.10.002. Epub 2009 Oct 30.
Thrombosis is a rare complication of cytomegalovirus (CMV) infection in immunocompetent patients. The clinical circumstances of this complication have never been studied, to the best of our knowledge.
We reviewed all reports on CMV-associated thrombosis in immunocompetent adults found in the literature, in search for thrombosis risk factors other than CMV.
Our search yielded 32 case reports and case series on CMV-associated thrombosis in immunocompetent adults. Reports on immunocompromised patients, infants and elderly patients were excluded. All reports were reviewed for other, acquired as well as inherited, predispositions for thrombosis.
Reports on 39 immunocompetent adults were reviewed, mean age for which was 34.9+/-10.8years. Overall, 14 (35.9%) patients had one or more acquired predispositions for thrombosis; 16 (45.7%) of the 35 patients that were investigated for inherited thrombophilias had one or more inherited predispositions for thrombosis. Only 12 (34.3%) patients were found to have no acquired or inherited predispositions for thrombosis other than CMV. The most common (n=13; 33.3%) acquired predisposition for thrombosis was daily use of oral contraceptives. The most common (n=6; 17.1%) inherited predisposition for thrombosis was factor V Leiden mutation.
Most immunocompetent adults with CMV-associated thrombosis have other acquired or inherited predispositions for thrombosis. Hence, addressing these predispositions in patients with CMV-associated thrombosis may be of great clinical importance.
巨细胞病毒（CMV）感染在免疫功能正常的患者中很少引起血栓形成。据我们所知，这种并发症的临床情况从未被研究过。
我们回顾了文献中所有关于免疫功能正常成人中与 CMV 相关的血栓形成的报告，以寻找除 CMV 以外的血栓形成危险因素。
我们的搜索结果产生了 32 篇关于免疫功能正常成人中与 CMV 相关的血栓形成的病例报告和病例系列。排除了免疫功能低下患者、婴儿和老年患者的报告。所有报告均回顾了其他获得性和遗传性血栓形成倾向。
共回顾了 39 例免疫功能正常的成年人的报告，平均年龄为 34.9+/-10.8 岁。总体而言，14 例（35.9%）患者存在一种或多种获得性血栓形成倾向；35 例接受遗传性血栓形成倾向检查的患者中，16 例（45.7%）存在一种或多种遗传性血栓形成倾向。只有 12 例（34.3%）患者除 CMV 外，无其他获得性或遗传性血栓形成倾向。最常见的（n=13；33.3%）获得性血栓形成倾向是每日使用口服避孕药。最常见的（n=6；17.1%）遗传性血栓形成倾向是因子 V 莱顿突变。
大多数患有 CMV 相关性血栓形成的免疫功能正常的成年人存在其他获得性或遗传性血栓形成倾向。因此，在患有 CMV 相关性血栓形成的患者中解决这些倾向可能具有重要的临床意义。
