Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
Nucl Med Biol. 2010 Jan;37(1):73-6. doi: 10.1016/j.nucmedbio.2009.08.008. Epub 2009 Oct 3.
Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [(11)C]phosgene, some difficulties, especially in the formation of [(11)C]phosgene process from [(11)C]CCl(4), hamper its use. The present article shows a simple preparation method for [(11)C]phosgene.
[(11)C]CCl(4) was obtained using the conventional method by passing a mixture of [(11)C]CH(4) and Cl(2) through a heated quartz tube. The [(11)C]CCl(4) was transformed to [(11)C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl(4) concentration measurement at room temperature with a flow rate of 50 ml/min.
This tube successfully transformed [(11)C]CCl(4) to [(11)C]phosgene at room temperature. [(11)C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility.
A high yield and reliable [(11)C]phosgene production method using a gas detector tube system for working-environmental CCl(4) concentration measurement was developed.
碳-11 标记光气是正电子发射断层扫描（PET）分子探针的重要标记前体。尽管[(11)C]光气很有用，但一些困难，尤其是从[(11)C]CCl(4)形成[(11)C]光气的过程中的困难，阻碍了它的使用。本文展示了一种简单的[(11)C]光气制备方法。
采用常规方法，将[(11)C]CH(4)和 Cl(2)的混合物通过加热的石英管，得到[(11)C]CCl(4)。[(11)C]CCl(4)在室温下以 50ml/min 的流速通过 Kitagawa 气体检测系统的预处理管，简单地转化为[(11)C]光气，用于工作环境 CCl(4)浓度的测量。
该管在室温下成功地将[(11)C]CCl(4)转化为[(11)C]光气。在短的合成时间内，以近 80%的放射化学产率（EOB）获得[(11)C]光气，具有高重现性。
开发了一种使用用于工作环境 CCl(4)浓度测量的气体检测管系统，以高收率和可靠地生产[(11)C]光气的方法。
