3,3'-(1,4-亚苯基）-双[2-烷氧基羰基-烷基）-2-硫代苯并恶磷杂环戊烷]的合成、光谱特性和生物测定。

Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].

机构信息

Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh 517 502, India.

出版信息

Eur J Med Chem. 2010 May;45(5):1828-32. doi: 10.1016/j.ejmech.2010.01.019. Epub 2010 Jan 20.

DOI:10.1016/j.ejmech.2010.01.019

PMID:20122766

Abstract

Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran-toluene in the presence of triethylamine at reflux temperature. These compounds were characterized by IR, 1H, 13C, 31P NMR and were found to exhibit potent in vitro antioxidant activity.

摘要

3,3'-(1,4-亚苯基)-双[2-烷氧基羰基-烷基)-2-硫代苯并恶磷杂环戊二烯]（3a-j）的合成都通过两步法完成。它包括先制备一氯中间产物（2），然后在三乙胺存在下，在回流温度下，在干燥的四氢呋喃-甲苯中与氨基酸酯反应。这些化合物通过 IR、1H、13C、31P NMR 进行了表征，并被发现具有很强的体外抗氧化活性。