Department of Organic Chemistry and Bio-technology, Sri Venkateswara University, Tirupati-517 502, India.
Eur J Med Chem. 2011 May;46(5):1798-802. doi: 10.1016/j.ejmech.2011.02.038. Epub 2011 Feb 23.
A new series of tetraphenyl bisphosphonates have been elegantly synthesized by one-pot method and were characterized by elemental analysis, FTIR, 1H, 13C, 31P NMR, mass spectra and evaluated for their in vitro antibone resorptive activity by inhibiting growth of osteoclasts. Two bisphosphonates 3g and 3f showed marked inhibition ratio (8 μM and 10 μM) and emerged as lead compounds. All compounds were tested for their antioxidant (DPPH scavenging, reducing power and inhibition of lipid peroxidation). They exhibited potent in vitro antioxidant activity dose-dependently.
已通过一锅法巧妙合成了一系列新的四苯基亚膦酸酯，并通过元素分析、FTIR、1H、13C、31P NMR、质谱进行了表征，并通过抑制破骨细胞生长来评估其体外抗骨吸收活性。两种双膦酸盐 3g 和 3f 表现出明显的抑制率（8 μM 和 10 μM），并成为先导化合物。所有化合物均进行了抗氧化（DPPH 清除、还原能力和抑制脂质过氧化）测试。它们表现出与剂量相关的有效体外抗氧化活性。
