Department of Chemical Engineering and Biotechnology, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK.
Int J Pharm. 2010 Apr 15;389(1-2):1-9. doi: 10.1016/j.ijpharm.2009.12.058. Epub 2010 Feb 1.
An experimental investigation of extrusion-spheronisation (E-S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion-spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC.
本文报道了一种新型微晶纤维素（MCC）配方的挤出造球（E-S）的实验研究，该配方以二甲基亚砜（DMSO）为造粒液。比较了 DMSO/MCC 糊剂的挤出造球性能与类似的水/MCC 制剂的性能，并使用润滑挤压流同样评估了它们的流变性能。涉及水、DMSO 和无水乙醇的案例研究提供了有关溶剂适合挤出 MCC 所需的物理化学性质的重要信息。
