Provost P J, Stick J A, Patterson J S, Hauptman J G, Robinson N E, Roth R
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314.
Am J Vet Res. 1991 Feb;52(2):289-97.
Large colon torsion frequently is a fatal condition in horses. The purpose of the study reported here was to determine systemic arterial pressure, plasma eicosanoid concentrations, colonic blood flow, vascular resistance, tissue pH, and morphologic features associated with large colon torsion and detorsion, and to evaluate the effects of sodium heparin (80 IU/kg of body weight, IV) treatment on these values. Values were determined in 20 anesthetized ponies that were randomly assigned into 4 equal groups: control; control/heparin; torsion; torsion/heparin. Torsions were created by a 720 degrees rotation of the cecum and colon around their long axes at the sternal and diaphragmatic flexures. After 1 hour of torsion, the torsion was corrected and the colon was allowed to reperfuse for 1 hour. Heparin was administered 30 minutes into the experiment. Parametric data were analyzed (P less than or equal to 0.05), using split-plot analysis of variance, with differences between means evaluated with a modified Bonferroni t test; histopathologic data were analyzed (P less than or equal to 0.05) with a Kruskal-Wallis one-way analysis of variance by ranks. Heparin prevented colonic detorsion-induced hypotension and increases in vascular resistance and thromboxane concentration, and it significantly increased colonic blood flow for 40 minutes during reperfusion. Heparin did not alter prostacyclin concentration or the histologic appearance of the large colon.
大结肠扭转在马匹中常常是一种致命疾病。本文报道的这项研究的目的是确定与大结肠扭转及扭转复位相关的全身动脉压、血浆类二十烷酸浓度、结肠血流量、血管阻力、组织pH值以及形态学特征，并评估静脉注射肝素钠（80国际单位/千克体重）治疗对这些数值的影响。在20匹麻醉的矮种马中测定各项数值，这些矮种马被随机分为4个相等的组：对照组；对照/肝素组；扭转组；扭转/肝素组。通过在胸骨和膈曲处将盲肠和结肠绕其长轴旋转720度来造成扭转。扭转1小时后，纠正扭转并使结肠再灌注1小时。在实验进行30分钟时给予肝素。参数数据采用裂区方差分析进行分析（P≤0.05），组间均值差异采用改良的Bonferroni t检验进行评估；组织病理学数据采用Kruskal-Wallis秩和单向方差分析进行分析（P≤0.05）。肝素可预防结肠扭转复位引起的低血压以及血管阻力和血栓素浓度的升高，并且在再灌注期间显著增加结肠血流量达40分钟。肝素不会改变前列环素浓度或大结肠的组织学外观。
