Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Epidemiology, Statistics and Prevention Research, Rockville, Maryland, USA.
Environ Health Perspect. 2010 Feb;118(2):297-302. doi: 10.1289/ehp.0901150.
Prenatal and postnatal polychlorinated biphenyl (PCBs) exposure has been associated with decrements in fetal and infant growth and development, although exposures during the preconception window have not been examined despite recent evidence suggesting that this window may correspond with the highest serum concentrations.
We assessed maternal serum PCB concentrations at two sensitive developmental windows in relation to birth weight.
Serum samples were collected from 99 women as they began trying to become pregnant (preconception) and after a positive pregnancy test (prenatal); 52 (53%) women gave birth and represent the study cohort. Using daily diaries, women recorded sexual intercourse, menstruation, and home pregnancy test results until pregnant or up to 12 menstrual cycles with intercourse during the estimated fertile window. With gas chromatography with electron capture, 76 PCB congeners were quantified (nanograms per gram serum) and subsequently categorized by purported biologic activity. Serum PCBs were log-transformed and entered both as continuous and categorized exposures along with birth weight (grams) and covariates [smoking (yes/no), height (inches), and infant sex (male/female)] into linear regression.
A substantial reduction in birth weight (grams) was observed for women in the highest versus the lowest tertile of preconception antiestrogenic PCB concentration (beta; = 429.3 g, p = 0.038) even after adjusting for covariates (beta; = 470.8, p = 0.04).
These data reflect the potential developmental toxicity of antiestrogenic PCBs, particularly during the sensitive preconception critical window among women with environmentally relevant chemical exposures, and underscore the importance of PCB congener-specific investigation.
产前和产后多氯联苯（PCBs）暴露与胎儿和婴儿生长发育受损有关，尽管在受孕前窗口期的暴露尚未得到研究，尽管最近有证据表明该窗口期可能与血清浓度最高相对应。
我们评估了 99 名女性在受孕前（受孕前）和妊娠试验阳性后（产前）两个敏感发育窗口期的母体血清 PCB 浓度与出生体重的关系。
在开始尝试怀孕时（受孕前）和怀孕测试阳性后（产前）收集 99 名女性的血清样本；52 名（53%）女性分娩，代表研究队列。女性使用每日日记记录性行为、月经和家庭妊娠测试结果，直到怀孕或在估计的可育窗口内进行 12 个月经周期的性交。使用气相色谱法和电子捕获法，定量了 76 种 PCB 同系物（纳克/克血清），并根据潜在的生物学活性进行了分类。血清 PCB 进行对数转换，并以连续和分类暴露的形式与出生体重（克）和协变量[吸烟（是/否）、身高（英寸）和婴儿性别（男/女）]一起输入线性回归。
与受孕前抗雌激素 PCB 浓度最低三分位相比，最高三分位的女性出生体重（克）显著降低（β=429.3 克，p=0.038），即使在调整协变量后（β=470.8，p=0.04）。
这些数据反映了抗雌激素 PCB 的潜在发育毒性，尤其是在具有环境相关化学暴露的女性敏感受孕前关键窗口期，强调了 PCB 同系物特异性研究的重要性。
