Nakajima H, Yoshida Y
First Dept. of Internal Medicine, Hirosaki University School of Medicine.
Gan To Kagaku Ryoho. 1991 Apr;18(4):522-8.
In recent years, a great advance has been brought in an early detection of colorectal cancer, especially early colorectal cancer. But some controversies are present as follows: 1. Mass screening for colorectal cancer. Immunologic tests for fecal occult blood increased the sensitivity and specificity for detecting colorectal neoplasia without a question. However, this screening method has not proven to get the effectiveness in decreasing mortality of colorectal cancer, although a case control study is under way in our department. 2. Adenoma-carcinoma sequence or de nov carcinoma. These two theories on histogenesis of colorectal cancer are on "hot" discussion to be better understood. 3. Strip biopsy for colorectal lesions. This method is now begun to be introduced to apply for small type-II lesions of colon. 4. Others (barium enema or endoscopy, a new method of colonic preparation which replaces Brown's method, tumor marker in colorectal cancer etc.). Today's status and future prospects were made on these matters.
近年来，在结直肠癌尤其是早期结直肠癌的早期检测方面取得了巨大进展。但目前存在一些争议，如下：1. 结直肠癌的大规模筛查。粪便潜血免疫检测无疑提高了检测结直肠肿瘤的敏感性和特异性。然而，尽管我们科室正在进行一项病例对照研究，但这种筛查方法尚未被证明能有效降低结直肠癌的死亡率。2. 腺瘤-癌序列或新发癌。关于结直肠癌组织发生的这两种理论正在进行激烈讨论，以便更好地理解。3. 结直肠病变的条形活检。这种方法目前已开始被引入应用于结肠II型小病变。4. 其他（钡灌肠或内镜检查、取代布朗方法的结肠新准备方法、结直肠癌中的肿瘤标志物等）。对这些问题阐述了当前的状况和未来前景。
