Son Woo-Chan, Bell David, Taylor Ian, Mowat Vasanthi
Department of Pathology, Huntingdon Life Sciences, Alconbury, Huntingdon, Cambridgeshire, United Kingdom.
Toxicol Pathol. 2010 Feb;38(2):292-6. doi: 10.1177/0192623309359794. Epub 2010 Feb 2.
It is sometimes difficult to assess the relevance of tumors that occur in treated animals in short-term studies. This report is intended to establish a general profile of tumor occurrence in young Han Wistar rats. Data were collected and evaluated from 29 rat carcinogenicity studies and from a few 2-, 4-, 13-, and 26-week studies conducted between 1995 and 2009 at Huntingdon Life Sciences, UK. The route of administration was dietary, oral gavage, or inhalation, and the analysis was confined to sporadic deaths (decedents) in carcinogenicity studies. In Han Wistar rats, the most common and earliest occurring tumor was malignant lymphoma in both sexes, the earliest being seen in the 16th and 26th week in males and females, respectively. The incidence of malignant lymphoma was slightly higher in males than in females. The second most common type of tumor was brain tumors in males and mammary tumors in females. Compared with Sprague-Dawley rats, where the most common early tumor was pituitary tumor in females, the most common early tumor in Han Wistar rats was malignant lymphoma in both sexes. These early tumor profiles are consistent with the lifetime tumor occurrence in these strains.
在短期研究中，有时很难评估经处理动物身上出现的肿瘤的相关性。本报告旨在建立年轻的Han Wistar大鼠肿瘤发生情况的总体概况。数据收集自1995年至2009年在英国亨廷顿生命科学公司进行的29项大鼠致癌性研究以及一些为期2周、4周、13周和26周的研究。给药途径为饮食、灌胃或吸入，分析仅限于致癌性研究中的散发性死亡（死亡动物）。在Han Wistar大鼠中，最常见且最早出现的肿瘤是两性的恶性淋巴瘤，最早分别在雄性和雌性大鼠的第16周和第26周出现。恶性淋巴瘤的发病率雄性略高于雌性。第二常见的肿瘤类型是雄性的脑肿瘤和雌性的乳腺肿瘤。与Sprague-Dawley大鼠相比，其最常见的早期肿瘤是雌性的垂体肿瘤，而Han Wistar大鼠最常见的早期肿瘤是两性的恶性淋巴瘤。这些早期肿瘤概况与这些品系大鼠终生的肿瘤发生情况一致。
