Palumbo P J, O'Fallon W M, Osmundson P J, Zimmerman B R, Langworthy A L, Kazmier F J
Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minn.
Arch Intern Med. 1991 Apr;151(4):717-21.
The clinical, biochemical, and vascular laboratory measurements potentially associated with the development and/or progression of peripheral occlusive arterial disease (POAD) were assessed during a 4-year period in 110 normal control subjects, 112 patients with POAD without diabetes mellitus, 240 patients with diabetes mellitus without POAD, and 100 patients with diabetes mellitus and POAD. Age, history of hypertension or coronary heart disease, history of cigarette smoking, presence of POAD, systolic blood pressure, and beta-thromboglobulin level were associated with progression of POAD. A multivariate logistic regression model indicated that the presence of diabetes mellitus or POAD or both at baseline, decreased postexercise ankle-brachial index, increased arm systolic blood pressure, and current smoking were independently associated with progression of POAD. This study suggests that cessation of smoking and control of hypertension are essential treatment modifications to decrease the risk of progression of peripheral vascular disease in diabetic patients.
在4年期间，对110名正常对照者、112名无糖尿病的外周闭塞性动脉疾病（POAD）患者、240名无POAD的糖尿病患者以及100名患有糖尿病和POAD的患者，评估了可能与POAD发生和/或进展相关的临床、生化及血管实验室指标。年龄、高血压或冠心病病史、吸烟史、POAD的存在、收缩压以及β-血小板球蛋白水平与POAD的进展相关。多变量逻辑回归模型表明，基线时存在糖尿病或POAD或两者皆有、运动后踝臂指数降低、手臂收缩压升高以及当前吸烟与POAD的进展独立相关。本研究提示，戒烟和控制高血压是降低糖尿病患者外周血管疾病进展风险的重要治疗调整措施。
