Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan.
J Atheroscler Thromb. 2010 Feb 26;17(2):181-8. doi: 10.5551/jat.1354. Epub 2010 Feb 3.
Cardiovascular disease is becoming increasingly more problematic in Mongolia. The cardioankle vascular index (CAVI) and circulating C-reactive protein (CRP) are new atherosclerosis-related parameters, but no comparative studies of atherosclerotic parameters including CAVI and CRP are available between Mongolian and Japanese populations, such as disease populations of hypertension (HT) and diabetes mellitus (DM). Our study objective was to examine atherosclerotic profiles in HT and DM patients in both countries.
From a hospital-based population, 156 Mongolian outpatients with HT and DM (men: 46%, mean age: 57.1 years) and 156 age- and sex-matched Japanese outpatients with HT and DM (men: 46%, age: 57.7) were recruited. Body mass index (BMI), heart rate (HR), blood pressure (BP), pulse pressure (PP), ankle-brachial index (ABI), ultrasonographic carotid intima-media thickness (IMT), blood total cholesterol (T-Cho), glucose, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were measured, in addition to CAVI and CRP.
The levels of BMI, HR, BP, PP, insulin and IMT were significantly higher and T-Cho and glucose were significantly lower in the Mongolian patients in comparison to the Japanese patients. Particularly, the levels of CAVI (mean+/-SD) (8.1+/-1.1 vs. 8.8+/-1.2) and CRP(median[interquartile range])(0.05[0.03-0.12]vs. 0.19[0.09-0.42]mg/dL)were significantly higher in Mongolian than Japanese patients. These significant differences remained unchanged, even after taking into account multiple variables, including BP and HOMA-IR. In addition, except for CAVI in the subgroup of DM, generally similar trends regarding atherosclerotic parameters were seen in the subgroup by sex and disease (HT, DM and HT plus DM).
These findings suggest that Mongolian patients with HT and DM may be at higher risk for cardiovascular disease than Japanese patients.
心血管疾病在蒙古变得越来越成问题。心血管踝臂指数（CAVI）和循环 C 反应蛋白（CRP）是新的动脉粥样硬化相关参数，但蒙古人和日本人之间（如高血压（HT）和糖尿病（DM）患者），包括 CAVI 和 CRP 在内的动脉粥样硬化参数的比较研究尚未见报道。我们的研究目的是检查两国 HT 和 DM 患者的动脉粥样硬化情况。
从基于医院的人群中，招募了 156 名蒙古 HT 和 DM 门诊患者（男性：46%，平均年龄：57.1 岁）和 156 名年龄和性别匹配的日本 HT 和 DM 门诊患者（男性：46%，年龄：57.7 岁）。测量了体重指数（BMI）、心率（HR）、血压（BP）、脉搏压（PP）、踝臂指数（ABI）、超声颈动脉内膜中层厚度（IMT）、总胆固醇（T-Cho）、血糖、胰岛素和胰岛素抵抗的稳态模型评估（HOMA-IR），此外还测量了 CAVI 和 CRP。
与日本患者相比，蒙古患者的 BMI、HR、BP、PP、胰岛素和 IMT 水平显著升高，而 T-Cho 和血糖水平显著降低。特别是，蒙古患者的 CAVI（平均值+/-标准差）（8.1+/-1.1 比 8.8+/-1.2）和 CRP（中位数[四分位间距]）（0.05[0.03-0.12]比 0.19[0.09-0.42]mg/dL）水平明显高于日本患者。这些差异在考虑到包括 BP 和 HOMA-IR 在内的多个变量后仍然存在。此外，除了 DM 亚组中的 CAVI 外，在 HT、DM 和 HT 加 DM 疾病亚组中，动脉粥样硬化参数也存在相似的趋势。
这些发现表明，蒙古 HT 和 DM 患者发生心血管疾病的风险可能高于日本患者。
