The MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK.
Nat Rev Rheumatol. 2010 Feb;6(2):99-105. doi: 10.1038/nrrheum.2009.260.
Osteoporosis is a major public health problem through associated fragility fractures. The most common sites of fracture are the hip, spine and wrist, and these have an enormous health and economic impact. All fractures result in some degree of morbidity, but fractures at the hip are associated with the worst outcomes. The worldwide direct and indirect annual costs of hip fracture in 1990 were estimated at US$34.8 billion, and are expected to increase substantially over the next 50 years. Fracture incidence varies between populations, and is set to increase over coming decades as the global population becomes more elderly. This effect will be particularly marked in the developing world, which is additionally assuming more-westernized lifestyles that predispose to increased fracture risk. Strategies to target those at high risk of fracture have been developed, but preventative measures at the public health level are also urgently needed to reduce the burden of this devastating disease.
骨质疏松症是一个主要的公共卫生问题，与脆性骨折有关。最常见的骨折部位是髋部、脊柱和腕部，这些部位对健康和经济都有巨大的影响。所有骨折都会导致一定程度的发病率，但髋部骨折的后果最严重。1990 年，全球髋部骨折的直接和间接年度成本估计为 348 亿美元，预计在未来 50 年内将大幅增加。骨折发生率在不同人群之间存在差异，随着全球人口老龄化，未来几十年预计会增加。这种影响在发展中国家尤为明显，这些国家还承担着更多的西方化生活方式，这增加了骨折风险。已经制定了针对高骨折风险人群的策略，但也迫切需要在公共卫生层面采取预防措施，以减轻这种破坏性疾病的负担。
